Test ID PKUSC Phenylalanine and Tyrosine, Self-Collect, Blood Spot
Ordering Guidance
For follow-up of an abnormal newborn screen for potential phenylketonuria, order PKU / Phenylalanine and Tyrosine, Plasma.
Necessary Information
1. Patient's age is required.
2. Patient's street address, city, state, ZIP (postal) code, country, and home phone are required (post-office [PO] boxes are not acceptable delivery locations).
Specimen Required
Container/Tube: Blood Spot Card
Specimen Volume: 2 Blood spots
Additional Information:
1. Order test each time the patient is to collect a dried blood specimen at home and mail the specimen directly to Mayo Clinic Laboratories.
2. Order should be placed a minimum of 3 days prior to desired date of collection.
3. Enter patient's address information for each order created, including street address (post office [PO] boxes are not acceptable delivery locations), city, state abbreviation, zip code, country, and home phone number.
4. For each order, the Blood Spot Collection-Self Collect kit will be mailed directly to the patient for self-collection (delivery to a PO box will not occur).
5. For more information on how to collect blood spots, see the following:
-How to Collect a Dried Blood Spot Sample via fingerstick.
-Blood Spot Collection Instructions-Fingerstick
-Blood Spot Collection Instructions-Fingerstick-Spanish
Secondary ID
610508Useful For
Monitoring effectiveness of therapy in patients with hyperphenylalaninemia in a patient-collected specimen
This test is not sufficient for follow-up for abnormal newborn screening results or for establishing a diagnosis of a specific cause of hyperphenylalaninemia.
Specimen Type
Whole bloodSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Ambient (preferred) | 90 days | FILTER PAPER |
| Frozen | 90 days | FILTER PAPER | |
| Refrigerated | 90 days | FILTER PAPER |
Reject Due To
| Blood spot specimen that shows serum rings or has multiple layers | Reject |
| Insufficient specimen | Reject |
| Unapproved filter papers | Reject |
Reference Values
Phenylalanine: 27-107 nmol/mL
Tyrosine:
<4 weeks: 40-280 nmol/mL
≥4 weeks: 25-150 nmol/mL
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
0382U
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysForms
If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.