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HelpTest ID MPHNS Methylphenidate and Metabolite, Serum
Ordering Guidance
This test should only be ordered by healthcare professionals to monitor patients who have been prescribed methylphenidate or identify misuse/abuse.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL Serum
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Secondary ID
624101Useful For
Confirming drug exposure and monitoring serum concentrations of methylphenidate and ritalinic acid
Special Instructions
Specimen Type
Serum RedSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Methylphenidate:
4-25 ng/mL (Single-dose peak plasma concentration range in children given 10-15 mg dose)
Ritalinic acid:
80-250 ng/mL (Single-dose peak plasma concentration range in children given 10-15 mg dose)
Cutoff concentrations:
Methylphenidate: 1.0 ng/mL
Ritalinic acid: 1.0 ng/mL
Day(s) Performed
Thursday
Report Available
3 to 9 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
G0480
80360 (if appropriate for select payers)